Modern reproductive medicine is constantly evolving, and in addition to proven methods of assisted reproduction, it also offers new options for supporting patients with diminished ovarian reserve or endometrial issues. Among the most widely discussed are PRP (Platelet-Rich Plasma) therapy and exosome therapy, which utilize biologically active substances involved in the body’s natural regenerative processes.

These methods are not a substitute for standard infertility treatment or IVF. Their goal is to create a more favorable biological environment in the ovaries or endometrium, and they may be incorporated into an individualized treatment plan for selected patients.

What are exosomes?

Exosomes are microscopic extracellular vesicles that facilitate communication between cells. They contain biologically active molecules, such as proteins, lipids, and microRNAs, which can influence tissue regeneration, inflammatory processes, and the formation of new blood vessels.

In reproductive medicine, their potential use in supporting ovarian function and endometrial regeneration is being studied. However, the research is still in the developmental stage, and their use is not yet considered a standard recommended practice.

What is PRP therapy?

PRP (Platelet-Rich Plasma) is plasma rich in platelets prepared from the patient’s own blood. Platelets contain growth factors that naturally contribute to tissue healing and regeneration.

In reproductive medicine, PRP is administered either to the area around the ovaries or into the uterine cavity, depending on the individual indication. The procedure is minimally invasive and is performed on an outpatient basis or under short-term anesthesia.

How are PRP and exosomes used in ovarian treatment?

For women with reduced ovarian reserve or a poor response to hormonal stimulation, research is being conducted to determine whether these methods can support the biological environment of the ovaries.

The intended goal is:

• promotion of microcirculation,
• support for natural regenerative processes,
• alleviating local inflammation,
• creating more favorable conditions for existing follicles.

It is important to emphasize that these methods do not create new eggs or restore a naturally depleted ovarian reserve.

How are they used for endometriosis?

Successful embryo implantation also depends on the quality of the endometrium. In some patients, despite standard hormonal treatment, the endometrium does not grow sufficiently, or implantation failure occurs repeatedly.

In such cases, the potential use of PRP or exosomes to support the following is being investigated:

• regeneration of the uterine lining,
• blood flow to the endometrium,
• local cellular communication,
• to create more favorable conditions for embryo implantation.

For which patients might these methods be appropriate?

A doctor may consider prescribing them on a case-by-case basis, particularly for patients:

• with reduced ovarian reserve,
• with low AMH levels,
• of advanced reproductive age,
• with a repeated weak response to stimulation,
• after repeated IVF cycles with a low number of retrieved eggs,
• with a thin endometrium,
• in cases of repeated implantation failure.

A specialist always determines suitability after a comprehensive assessment of the patient’s health and reproductive history.

What does current scientific research say?

Both PRP and exosome therapy are promising areas of regenerative medicine. Some studies suggest a possible improvement in selected laboratory or ultrasound parameters in a subset of patients. However, the results to date are inconsistent, and further high-quality clinical studies are needed to confirm their efficacy.

Therefore, these methods are considered complementary, and their use must always be evaluated on a case-by-case basis.

What are the benefits?

Possible benefits of regenerative procedures may include:

• minimally invasive procedure,
• short recovery period,
• the option of combining it with IVF treatment,
• individualized approach,
• the use of the body's natural biological mechanisms.

However, treatment outcomes cannot be guaranteed, and each patient may respond differently.

Frequently Asked Questions

Is PRP or exosome therapy suitable for every patient?

No. The doctor determines suitability based on age, hormone test results, ultrasound findings, and reproductive history.

Can these methods produce new eggs?

No. Current scientific evidence does not support the claim that PRP or exosomes can create new eggs or restore a naturally depleted ovarian reserve.

Can they increase the success rate of IVF?

Some studies have shown encouraging results, but their effectiveness has not yet been conclusively confirmed. Therefore, they are used only in carefully selected patients as a supplement to standard treatment.

Regenerative medicine offers new options for supporting patients undergoing infertility treatment. Both PRP and exosome therapy are promising complementary methods aimed at supporting natural biological processes in the ovaries or endometrium.

If you are considering modern treatment options or would like to find out whether these procedures might be suitable for you, please schedule a consultation with our specialists. Based on a comprehensive examination, we will recommend a personalized treatment plan tailored to your diagnosis and reproductive goals.